Seafood Casserole Recipe

Jump To Recipe
Avatar Author's default profile picture
Carole Published: January 6, 2021 Modified: May 31, 2021
Seafood Casserole Recipe

How To Make Seafood Casserole

Creamy casserole from the East Coast made of layers of artichokes, shrimps, and scallops and a dollop of special sauce oven baked to perfection!




  • 1lbsourdough bread,1 medium load, roughly torn
  • 8tbspunsalted butter,1 stick, melted, divided
  • 1cupcheddar cheese,shredded
  • 3tspkosher salt,divided, plus more to taste
  • 4cupsdry white wine,plus 1 tbsp, divided
  • 1lbshrimp,16/20 count, peeled and deveined
  • 1lblarge scallops
  • 1lbjumbo lump crabmeat
  • 2cupshalf & half
  • 3tbspall-purpose flour
  • 1tspWorcestershire sauce
  • 1tsppaprika
  • 1tbsplemon juice
  • 2tbspketchup
  • 28ozartichoke heart,(2 cans) drained and chopped
  • chive,fresh, chopped, for garnish
  • lemon wedge,for serving


  1. Preheat the oven to 350 degrees F.

  2. Spread the bread in a single layer on a rimmed baking sheet and bake for 10 minutes, until lightly toasted.

  3. Let cool to room temperature. Leave the oven on.

  4. Add the toasted bread to a food processor and pulse until finely ground. You should have about 4 cups of bread crumbs.

  5. In a large bowl, combine the bread crumbs, 4 tablespoons of melted butter, the cheddar cheese, and 1 teaspoon of salt and toss to combine. Set aside.

  6. In a medium pot, combine 4 cups of white wine and a generous pinch of salt and bring to a boil over medium-high heat.

  7. Add the shrimp and cook until bright pink, about 1 minute. Use a spider or slotted spoon to transfer the shrimp to a colander to drain.

  8. Return the wine to a boil. Add the scallops and cook until just opaque, about 2 minutes. Transfer the scallops to a colander to drain.

  9. Chop the shrimp and scallops into bite-size pieces. Transfer to large bowl, along with the crab and 1 teaspoon of salt. Toss to combine.

  10. In a liquid measuring cup or medium bowl, whisk together the half-and-half, 3 tablespoons of melted butter, the flour, Worcestershire sauce, paprika, lemon juice, ketchup, remaining tablespoon of white wine, and remaining teaspoon of salt.

  11. Brush the remaining tablespoon of melted butter in a 9 by 13-inch baking dish.

  12. Scatter the artichokes in an even layer over the bottom of the baking dish.

  13. Scoop the seafood mixture over the artichokes. Pour the sauce over the seafood. Top with the bread crumb mixture.

  14. Bake the casserole for 20 to 25 minutes, or until bubbling and golden brown.

  15. Top with chives and serve with lemon wedges.


  • Calories: 689.96kcal
  • Fat: 26.94g
  • Saturated Fat: 15.51g
  • Trans Fat: 0.68g
  • Monounsaturated Fat: 6.81g
  • Polyunsaturated Fat: 1.91g
  • Carbohydrates: 52.53g
  • Fiber: 7.00g
  • Sugar: 8.62g
  • Protein: 40.46g
  • Cholesterol: 209.79mg
  • Sodium: 1481.48mg
  • Calcium: 352.09mg
  • Potassium: 977.70mg
  • Iron: 4.79mg
  • Vitamin A: 240.24µg
  • Vitamin C: 18.74mg
Continue Reading Below
Chat Bubble Icon Share your own special recipe
Submit Your Own Recipe

Have your own special recipe to share? Submit Your Recipe Today!

Continue Reading Below
Continue Reading Below

Related Recipes

Dip, Sauce & Condiment

Spicy Seafood Sauce

Take your shrimp tacos and other seafood favorites to a…
Total 5 mins
Seafood Boil Recipe

Seafood Boil

Shrimp, crawfish, and Manila clams are coated with a spicy…
Total 30 mins
easy seafood packs recipe
BBQ & Grilled

Easy Seafood Packs

Taste the refreshing flavors of the sea in these seafood…
Total 35 mins

Seafood Gumbo Stock

Level up your gumbos with his notably savory and rich…
Total 7 hrs 50 mins

Seafood Stuffing

Enjoy a rich and savory plate of seafood stuffing for…
Total 1 hr 25 mins
Continue Reading Below

Leave a comment

Replying to